Preheat the oven to 400°F and line a large sheet pan with parchment paper or foil for easy cleanup.
In a mixing bowl, stir together the honey, Dijon mustard, olive oil, minced garlic, salt, and black pepper until smooth.
Add the broccoli florets to the bowl and toss until they are evenly coated with about half of the honey mustard mixture.
Place the salmon fillets on the prepared sheet pan and brush the remaining honey mustard mixture over the top of each fillet.
Spread the coated broccoli around the salmon in a single layer so it has room to roast.
Bake for 15 to 18 minutes until the salmon flakes easily with a fork and the broccoli is tender with some browned edges.
Serve hot with lemon wedges on the side.