Rim four glasses with cinnamon sugar by running a lime wedge around the edge and dipping into the sugar.
Add the tequila, pumpkin puree, orange liqueur, lime juice, pumpkin pie spice, agave syrup, and ice to a blender.
Blend on high until the mixture is smooth and the ice is fully broken down.
Pour the blended mixture evenly into the prepared glasses.
Add a lime wedge to each glass before serving.