Preheat the oven to 350 degrees F. Place the brie wheel on a parchment-lined baking sheet.
Bake the brie for 15 minutes until the center feels soft when pressed lightly.
While the brie bakes, combine the cranberries, sugar, water, and orange juice in a small saucepan.
Bring the mixture to a simmer over medium heat and cook for 8 to 10 minutes, stirring occasionally, until the cranberries burst and the sauce thickens slightly.
Remove the brie from the oven and spoon the warm cranberry compote over the top.
Arrange crackers around the brie on a serving plate.